The Linda and Mike Mussallem Foundation
At a glance
This funder does not accept unsolicited applications. The foundation chooses the organisations it funds itself.
Key takeaways
- The Linda and Mike Mussallem Foundation funds healthcare innovation, Down syndrome health care, integrative whole-person health and congenital heart defects work, including through its Mussallem CHD Alliance initiative, so only organisations active in these areas should consider it.
- It operates by invitation only and does not accept unsolicited requests, so organisations should not approach it cold or without an existing connection.
- Its grants to organisations have ranged from $1,200,000 to $20,000,000, with a median of about $1,500,000, so any approach should be for a substantial sum rather than a modest one.
- With only 6 grants to organisations recorded and just 6% of grant dollars going to organisations it had funded before, this looks like a relationship-led funder rather than an open, competitive one.
- No geographic focus is stated, though its grants have so far been mainly in California and Massachusetts.
Overview
The Linda and Mike Mussallem Foundation is a US private foundation based in Wilmington, DE.
What they fund
Profile derived from the foundation's IRS Form 990-PF filings (TY2024, TY2023, TY2022) and its website, with every statement checked against those sources. Sources read on 7 October 2026.
Priority Areas
The foundation aims to harness the power of innovation and integrative health solutions to address complex health care challenges for overlooked populations in need. Its focus areas include next-generation healthcare innovation, Down syndrome health care and integrative/whole person health. It also describes the Mussallem CHD Alliance as a flagship initiative dedicated to people born with congenital heart defects. The foundation says it supports organisations that create community and prepare people with Down syndrome to succeed within society. Its approach emphasises innovation, whole-person health and changing lives for the better.
Themes
- Next-generation healthcare innovation
- Down syndrome health care
- Integrative whole-person health
- Congenital heart defects
Geographic Focus
No geographic focus is stated; the filings show grants mainly in California and Massachusetts.
How to apply
The foundation states that it does not accept unsolicited requests.
Application success factors
- Repeat giving: In its TY2024 filing, 6% of its grant dollars to organisations went to organisations it had also funded in its TY2022 or TY2023 filing.
- Grant size: Across its TY2022, TY2023 and TY2024 filings, half of its 6 grants to organisations were about $1,500,000 or less.
What the foundation says:
- The foundation is passionate about supporting organisations that create community and prepare people with Down syndrome to succeed within society.
Where grants go
From grants to organisations in the foundation’s filings for tax years 2022–2024.
Grant dollars by state
- The largest single recipient received 68% of grant dollars to organisations.
- In tax year 2024, 6% of grant dollars went to organisations The Linda and Mike Mussallem Foundation had funded in earlier filings.
- No grants were paid directly to organisations outside the US.
- 24% of grant dollars went to intermediaries that regrant to other organisations.
Grants
The largest grants to organisations in the foundation’s latest filing:
- Stanford University · Center for Biodesign$20,000,0002024 tax year
- Massachusetts General Hospital · Mussallem Transformative Scholars in ALS Research Award Fund and Translations of Human Neuron Screen Hits from the Lab$1,200,0002024 tax year
Grants to organisations listed in the foundation’s Form 990-PF filings. Grants to individuals are not shown.
Officers and directors
- Michael Mussallem — Director, President, Treasurer
- Linda Mussallem — Director, Secretary, VP
From the latest Form 990-PF filing
3 years of tax filings
| Year | Total expenses | Grants paid | Assets | Filing document |
|---|---|---|---|---|
| 2022 tax year | $4,521,533 | $4,074,727 | $87,022,373 | Filing for 2022 tax year |
| 2023 tax year | $4,695,718 | $4,151,218 | $104,577,296 | Filing for 2023 tax year |
| 2024 tax year | $22,209,442 | $21,200,000 | $98,792,716 | Filing for 2024 tax year |
Figures from the foundation’s IRS Form 990-PF filings. Assets are at fair market value at year end. The document icon links to each year’s filing on ProPublica Nonprofit Explorer.
Sources
Registers and filings
Other sources
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At a glance
Applying to The Linda and Mike Mussallem Foundation?
Hinchilla drafts your answers around this funder's priorities, using your organisation's own documents.
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Contact
- Wilmington, DE
- mussallemfoundation.org
Applying to The Linda and Mike Mussallem Foundation?
Hinchilla drafts your answers around this funder's priorities, using your organisation's own documents.
No credit card required
Contact
- Wilmington, DE
- mussallemfoundation.org